A Modified Mannich Reaction Using 1.3-Dioxolane.

The Redox-Mannich Reaction

A complement to the classic three-component Mannich reaction, the redox-Mannich reaction, utilizes the same starting materials but incorporates an isomerization step that enables the facile preparation of ring-substituted β-amino ketones. Reactions occur under relatively mild conditions and are facilitated by benzoic acid.

&Mannich Reaction Iridium-Catalyzed Reductive Nitro-Mannich Cyclization

A new chemoselective reductive nitro-Mannich cyclization reaction sequence of nitroalkyl-tethered lactams has been developed. Relying on the rapid and chemoselective iridium(I)-catalyzed reduction of lactams to the corresponding enamine, subsequent nitro-Mannich cyclization of tethered nitroalkyl functionality provides direct access to important alkaloid natural-product-like structures in yield...

A Modified Orcinol Reaction for RNA Determination

Sulfonated polystyrene/montmorillonite nanocomposite as a new and efficient catalyst for the solvent-free Mannich reaction

Sulfonated polystyrene/montmorillonite nanocomposite (OMMT/PS-SO3H) was prepared and used as a novel, efficient and inexpensive heterogeneous acid catalyst in the one-pot reaction three-component Mannich reaction of ketones, aromatic aldehydes and amines under solvent-free conditions. The catalyst was characterized by XRD, SEM, TG, BET and FT-IR techniques. This method has advantages...

A Study on the Mannich Reaction with 1,3-Indandione

A ttem pted M annich reaction with the title com pound 1 using m orpholine and formalin led to 2 or 4 according to the reaction conditions. W hereas, on using prim ary amines the diindeno [l,2-b:2 ',l'-e]pyridine (9 -1 1 ) were obtained, in addition to 2-methylene1,3-indandione (6 ), in case o f 10 and 11. However, the M annich bases 1 3 -1 5 were form ed on treating 2-benzylidene-1,3-indandion...